Posted on: Thursday, 22 May 2008, 11:52 CDT
Plexxikon has announced positive data from preclinical studies of polycystic kidney disease demonstrating significantly reduced kidney disease following treatment with Plexxikon's novel drug candidate.
In the preclinical study of Plexxikon's polycystic kidney disease (PKD) drug candidate, doses of the drug candidate were administered orally daily for 14 days. A marked reduction in kidney cyst burden was observed in the treatment group compared to vehicle treated mice.
Levels of blood urea nitrogen, an indicator of kidney function, were also significantly improved in the drug-treated groups compared with the vehicle-treated group, suggesting that improved renal function accompanied reduced cyst growth in treated animals.
Plexxikon's novel small molecule kinase inhibitor is said to be a highly selective and potent inhibitor of Raf kinase, a critical mediator of PKD pathology.
Source: Datamonitor
Wednesday, May 28, 2008
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An open letter about research misconduct on polycystic kidney diseases (PKD) was published on Nature comments online. Please see the following link:
http://www.nature.com/news/2008/080618/full/453969d.html
Help needed to fight research misconduct
I worked in one of the most prestigious institutes in Boston and the world. In the work, I could not be able to recapitulate and develop a major story in the polycystic kidney disease field. Later I found out that some of the important data that were published and used by the laboratory to apply for NIH grants were falsified and fabricated. Astoundingly, my findings also indicated that several top laboratories in the field were probably involving in fabrication and/or falsification of scientific data. I presented the evidences and made complaints to the principle investigator of the laboratory and later the officials in the institute. However, I was retaliated against for my whistle blowing and was asked to leave my position. I have made research misconduct allegation and retaliation allegation in Office of Research Integrity in US Department of Health and Human Services. Unfortunately, ORI only asked the institute set up self-investigation panels for both issues. After my complaining, the institute egregiously engaged in the retaliation and threatening, attempting to intimidate me. After an extremely unfair investigation, the institute terminated my position before the investigation to research misconduct actually started, releasing a clear signal to the people of research misconduct that the institute is helping them cover up their wrongdoings. If the research misconduct is covered up, millions dollars of taxpayers' money could be in danger of being wasted, the public health could be in danger of unprotected, and the truth might be buried by the lies. Therefore, I am seeking for urgent assistance from anyone who will be able to give me a hand on this matter. Your kind assistance and/or information will be highly appreciated by all honest and hard-working scientists. If you are interested in knowing the specific story, please contact me at lincbacon@yahoo.com.
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